Adriamycin and Daunomycin Generate Reactive 0 xygen Compounds in Erythrocytes
نویسندگان
چکیده
Adriamycin and daunomycin produce glutathione, by ‘4C-formate oxidation, dose-related cardiac toxicity that may be and by the catalase-aminotriazole trapping related to oxygen radicals. Addition of technique. These experiments indicate these compounds to human erythrocyte that Adriamycin and daunomycin interact suspensions resulted in stimulation of with oxyhemoglobin to generate reactive hexose monophosphate shunt activity that oxygen metabolites. A similar interaction was markedly impaired in the absence of with oxymyoglobin may occur in the oxyhemoglobin. Evidence for generation heart and produce oxygen radicals that inof hydrogen peroxide by these compounds jure cardiac myocytes. was provided by oxidation of reduced
منابع مشابه
Adriamycin and daunomycin generate reactive oxygen compounds in erythrocytes.
Adriamycin and daunomycin produce dose-related cardiac toxicity that may be related to oxygen radicals. Addition of these compounds to human erythrocyte suspensions resulted in stimulation of hexose monophosphate shunt activity that was markedly impaired in the absence of oxyhemoglobin. Evidence for generation of hydrogen peroxide by these compounds was provided by oxidation of reduced glutathi...
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